Spravatotm (Esketamine) Therapy
SpravatoTM (Esketamine) is derived from Ketamine, an anesthetic that has also been used for many years to treat depression.Ketamine’s intended use is for those with treatment-resistant depression.
But it wasn’t until recently that SpravatoTM (Esketamine) earned FDA approval specifically for use as a nasal spray for those with treatment-resistant depression.
SpravatoTM (Esketamine) is a prescription medicine, used along with an antidepressant taken by mouth to treat:
Adults with treatment-resistant depression (TRD)
Depressive symptoms in adults with major depressive disorder (MDD) with suicidal thoughts or actions
The U.S. Food and Drug Administration approved SpravatoTM (Esketamine) nasal spray, in conjunction with an oral antidepressant, for the treatment of depression in adults who have tried other antidepressant medicines but have not benefited from them (treatment-resistant depression).
The patient self-administers SpravatoTM nasal spray under the supervision of a health care provider in a certified medical office. This medication can not be taken home.
Research suggests that untreated depression causes long-term brain damage and is a risk factor for dementia. Studies show that people with depression have up to 20% shrinkage of the hippocampus, a region of the brain critical for memory and learning. But SpravatoTM (Esketamine) may counteract the harmful effects of depression.
Studies indicate that connections between brain cells diminish under chronic stress, but SpravatoTM (Esketamine) reverses these stress-related changes. “Esketamine is different than any other antidepressant in that it not only prevents the neurotoxic effects of depression on the brain, but it also seems to have a growth-promoting effect,” explains Adam Kaplin, M.D., Ph.D., a psychiatrist with Johns Hopkins Medicine.
Adam Kaplin, M.D., Ph.D, Psychiatrist
Johns Hopkins Medicine
SpravatoTM (Esketamine) works through a different mechanism than other antidepressants. While antidepressants increase levels of chemicals such as serotonin, norepinephrine and dopamine. Having greater quantities of these neurotransmitters allows for better communication between the brain and positive affects of your mood.
SpravatoTM (Esketamine) works like conventional antidepressants, but unlike antidepressants it increases levels of glutamate (most abundant chemical messenger in the brain). The result is a greater impact on more brain cells at one time.