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SPRAVATOTM 
(ESKETAMINE) THERAPY

SPRAVATOTM (ESKETAMINE) TREATMENT CENTER
ANNAPOLIS, MARYLAND

SpravatoTM (Esketamine) is used as a general anesthetic and as an antidepressant for treatment of depression. It is specifically used as a therapy for treatment-resistant depression (TRD) and for major depressive disorder (MDD) with co-occurring suicidal ideation or behavior.

EFFECTIVE FOR TREATMENT-RESISTANT DEPRESSION

SpravatoTM (Esketamine) is derived from Ketamine, an anesthetic that has also been used for many years to treat depression. Ketamine’s intended use is for those with treatment-resistant depression. But it wasn’t until recently that SpravatoTM (Esketamine) earned FDA approval specifically for use as a nasal spray for those with treatment-resistant depression.

WHAT IS
SPRAVATOTM
(ESKETAMINE) TREATMENT LIKE?

Treatment with SpravatoTM (Esketamine) nasal spray is done on an outpatient basis, following a doctors’ prescription. With the nasal spray, you give yourself three doses, spaced five minutes apart, under supervision. You remain in the clinic under medical observation until potential side effects have passed.

WHAT IS SPRAVATOTM (ESKETAMINE)?

SpravatoTM (Esketamine) is a prescription medicine, used along with an antidepressant taken by mouth to treat:

Adults with treatment-resistant depression (TRD)

Depressive symptoms in adults with major depressive disorder (MDD) with suicidal thoughts or actions

The U.S. Food and Drug Administration approved SpravatoTM (Esketamine) nasal spray, in conjunction with an oral antidepressant, for the treatment of depression in adults who have tried other antidepressant medicines but have not benefited from them (treatment-resistant depression).

The patient self-administers SpravatoTM nasal spray under the supervision of a health care provider in a certified medical office. This medication can not be taken home.

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SPRAVATOTM (ESKETAMINE) HELPS THE BRAIN FORM NEW CONNECTIONS

Research suggests that untreated depression causes long-term brain damage and is a risk factor for dementia. Studies show that people with depression have up to 20% shrinkage of the hippocampus, a region of the brain critical for memory and learning. But SpravatoTM (Esketamine) may counteract the harmful effects of depression.

Studies indicate that connections between brain cells diminish under chronic stress, but SpravatoTM (Esketamine) reverses these stress-related changes. “Esketamine is different than any other antidepressant in that it not only prevents the neurotoxic effects of depression on the brain, but it also seems to have a growth-promoting effect,” explains Adam Kaplin, M.D., Ph.D., a psychiatrist with Johns Hopkins Medicine.

”“Esketamine is different than any other antidepressant in that it not only prevents the neurotoxic effects of depression on the brain, but it also seems to have a growth-promoting effect.”

Adam Kaplin, M.D., Ph.D, PsychiatristJohns Hopkins Medicine

HOW DOES SPRAVATOTM (ESKETAMINE) TREAT DEPRESSION?

SpravatoTM (Esketamine) works through a different mechanism than other antidepressants. While antidepressants increase levels of chemicals such as serotonin, norepinephrine and dopamine. Having greater quantities of these neurotransmitters allows for better communication between the brain and positive affects of your mood.

SpravatoTM (Esketamine) works like conventional antidepressants, but unlike antidepressants it increases levels of glutamate (most abundant chemical messenger in the brain). The result is a greater impact on more brain cells at one time.

KETAMINE ASSISTED PSYCHOTHERAPY (KAP)

Ketamine Assisted Psychotherapy (KAP) is a new and specialized form of therapy that takes place after your ketamine treatment. It involves psychotherapists who have experience with and knowledge about ketamine and its effects on the brain. It is recommended to have a mental health provider navigate your journey after your ketamine treatment. We provide this service with your own therapist, or at an additional charge with one of our trusted providers in our office.

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